Research library
Beta-Casein Studies in Infants and Children
Research on beta-casein variants and infant formula, growth, gastrointestinal comfort and early-childhood outcomes.
9 studies
All studies →Effect of Infant Formula Made With Milk Free of A1-Type β-Casein on Growth and Comfort: A Randomized Controlled Trial
From satisfaction surveys, a significantly higher percentage of the A1PF group had relieved gastrointestinal symptoms, reduced vomiting after feeding, improved digestion, and better stool characteristics (p < 0.05). Both formulas were generally well tolerated. Among mixed-fed infants, those who consumed A1PF infant formula had the same growth as those fed CON infant formula, and improved comfort (including relieved gastrointestinal symptoms and fewer crying episodes).
Effect of β-casein A2 cow milk supplementation on physical growth, inflammation, growth, and metabolism hormonal profiles in stunted children
This study suggests that β-casein A2 milk supplementation was associated with improvements in physical growth and related biomarkers in stunted children. Additionally, β-casein A2 milk may produce fewer BCM-7 metabolites compared to β-casein A1 milk, which has been hypothesized to be associated with certain adverse health outcomes. However, further controlled studies are needed to confirm its efficacy as a dietary intervention.
Effects of A1-type β-casein protein free bovine milk on mothers and infants: a randomized double-blind controlled trial
Compared with mothers who drank conventional cow's milk, full-term mothers who drank A1PF milk showed lower levels of gastrointestinal and systemic inflammatory markers and improved gastrointestinal symptoms, and this effect may also be transmitted to full-term breastfed infants. This conclusion requires further research to confirm.
Effect of A1 protein-free formula versus conventional formula on acute respiratory infections and diarrhea in toddlers: A Randomized Controlled Trial
Toddlers who consumed A1PF had a reduced duration of ARI and improved diarrhea outcomes, reducing the burden on their families compared with toddlers who consumed CON. Although this is consistent with other studies, further research is required to determine whether these effects are solely attributable to the A1PF milk base or other differences between the formulas.
An A2 β-casein infant formula with high sn-2 palmitate and casein phosphopeptides supports adequate growth, improved stool consistency, and bone strength in healthy, term Chinese infants: a randomized, double-blind, controlled clinical trial
The study suggests that the A2 β-casein formula with high sn-2 palmitate and CPP supports adequate growth, is well tolerated, and may have beneficial effects on stool consistency, gastrointestinal comfort, crying duration, and bone density, comparable to HM.
Effectiveness of Growing-Up Milk Containing Only A2 β-Casein on Digestive Comfort in Toddlers: A Randomized Controlled Trial in China
Growing-up milk containing only A2 β-casein were well-tolerated and associated with lower parent-reported constipation scores after two weeks when compared to conventional milks. In healthy toddlers with minor GI distress, A2 GUM improved overall digestive comfort and GI-related symptoms within one week.
Effects of Conventional Milk Versus Milk Containing Only A2 β-Casein on Digestion in Chinese Children: A Randomized Study
Replacing conventional milk with milk containing only A2 β-casein reduced gastrointestinal symptoms associated with milk intolerance in Chinese preschool children, with corresponding improvements in aspects of cognitive performance.
The exogenous opioid peptides and DPPIV serum activity in infants with apnoea expressed as apparent life threatening events (ALTE)
Casein-derived peptides have been suggested to play a role in sudden infant death syndrome (SIDS). In this study, we have determined the content of bovine β-casomorphin-7 (bBCM-7) and the activity of dipeptidyl peptidase-IV (DPPIV) in sera of infants with apparent life threatening events (ALTE syndromes, 'near miss SIDS'). We have found that the sera of some infants after an apnoea event contained more β-casomorphin-7 than that of the healthy infants in the same age.
Beta-Casomorphins-7 in infants on different type of feeding and different levels of psychomotor development
The data indicate that breast feeding has an advantage over artificial feeding for infants' development during the first year of life and support the hypothesis for deterioration of bovine casomorphin elimination as a risk factor for delay in psychomotor development and other diseases such as autism.